To advance -deficiency constitution research, future development should focus on objective identification, establishment of animal models, rigorous research on the constitution and relevant diseases, and a comprehensive analysis of the entire spectrum of nine constitutions. This will help produce more scientifically grounded and objective conclusions.

A study into acupuncture prescription efficacy for functional gastrointestinal disorders (FGIDs), exploring the special, co-effect, or synergistic outcomes, considering the characteristics of single or compatible acupoints and the variations in acupuncture techniques, will be undertaken.
Based on the search strategy, six electronic bibliographic databases were consulted, producing a summary for this overview.
The accumulated data strongly suggests that acupuncture possesses therapeutic value in the management of FGIDs. Despite this, the intervention's prescription involved diverse single acupoints, compatible acupoints, and expert-validated acupoints.
Fundamental to the core acupoints, including Tianshu (ST25), Zusanli (ST36), and Shangjuxu (ST37), are the specific acupoints, meridian points, and nerve segments, and the bi-directional regulatory effect observed in this study underlies the selection and prescription of acupoints for acupuncture treatment of FGIDs.
The application of acupoints, including Tianshu (ST25), Zusanli (ST36), and Shangjuxu (ST37), in the acupuncture treatment of functional gastrointestinal disorders (FGIDs), as demonstrated in this study, emphasizes the importance of specific acupoints, related meridian points, and nerve segments, where the two-way regulatory effects serve as a vital basis for acupoint selection and treatment prescriptions.

In preliminary investigations of Yinyanghuo's and its extract's potential mechanism in COPD treatment, bioinformatics strategies will be coupled with meta-analysis.
A meta-analytic investigation was performed as the first step. A systematic review of Chinese and English literature related to Yinyanghuo's COPD treatment was conducted by combining subject terms with broader keywords. Employing the SYRCLE risk bias assessment tool, the included studies were evaluated, and effect quantities were aggregated by the review manager software for statistical analysis. By employing bioinformatics, Yinyanghuo's active ingredients and their targets were scrutinized, and the overlapping genes were obtained by correlating them to COPD targets. The medicinal materials-compounds-targets model was developed, leading to the annotation of its key pathways. At last, the primary focus was attached to its requisite compounds.
Eight studies were part of this meta-analysis's dataset. Analysis of the results revealed a significant downregulation of pro-inflammatory cytokines like tumor necrosis factor- (TNF-) and interleukin (IL)-8, coupled with an upregulation of anti-inflammatory and antioxidant factors, including IL-10 and phospho-protein kinase B (p-AKT), in the COPD model treated with Yinyanghuo (Herba Epimedii Brevicornus). All observed differences were statistically significant (all P < 0.05). From Yinyanghuo (Herba Epimedii Brevicornus), bioinformatics analysis yielded 23 active components and 102 corresponding target genes. Of particular note were 17 compounds and 63 targets exhibiting a significant relationship with Chronic Obstructive Pulmonary Disease (COPD). cancer-immunity cycle Enrichment analysis showed a prevalence of TNF signaling, PI3K/Akt signaling, cancer signaling, and various inflammation-related pathways, oxidative stress mechanisms, and tumor-related processes. Analysis of molecular docking simulations for the top 5 components of 24-epicampesterol against 10 core targets, including IL-6, demonstrated binding energies all falling below 50 kcal/mol, suggesting strong binding potential.
According to bioinformatics and meta-analysis, the therapeutic effect of Yinyanghuo, including its constituent parts, against COPD may stem from its ability to neutralize inflammation and oxidative stress. Early results point to Yinyanghuo's promising role as a natural approach to COPD prevention and treatment.
Meta-analysis and bioinformatics data point to a possible relationship between Yinyanghuo and its components' therapeutic efficacy against COPD, which might involve opposing the effects of inflammation and oxidative stress. check details These findings provide an initial framework for exploring Yinyanghuo as a natural COPD preventative and curative agent.

Treatment for 50% of knee osteoarthritis (KOA) patients in China involves Traditional Chinese Medicine or a combination thereof with Western medicine, demanding objective evaluations for efficacy. The primary approaches employed were multi-source data collection, processing, and fusion, exemplified by prospective clinical trials involving 150 KOA patients and 100 healthy individuals. With the help of a tongue inspection application, an infrared instrument, and a channel instrument, among others, data were gathered. The multi-source data was analyzed, screened, fused, and modeled. Combining traditional clinical tests with a custom-designed information platform in this research provides convenience for clinical procedures, medical follow-ups, and immediate feedback for statistical data analysis.

In patients with malignant tumors treated with radical mastectomy, suppression of cellular immune function might occur, thereby impacting their quality of life (QOL). Following radical mastectomy for breast cancer, adjuvant therapy is often complicated by immune suppression, which leads to adverse reactions and complications. Currently, a dearth of demonstrably successful treatments exists for the suppression of the immune system. Subsequently, the need for a new treatment paradigm is evident. Clinical practice frequently utilizes the press needle. Although many other variables have been assessed, the effects of press needles on postoperative immune responses have been evaluated in a small percentage of studies. This research project seeks to determine the relationship between press needle usage and immune function and quality of life in women diagnosed with breast cancer who have undergone radical mastectomy. This single-center, randomized, and single-blinded trial constitutes the methodology for this investigation. Randomization, at a 11:1 ratio, will allocate 78 eligible patients between the press needle group and the sham press needle group. Each week, for two weeks, during the treatment period, patients will receive verum press needle or sham press needle five times. As the primary outcome measures, the peripheral blood levels of CD8+, CD4+, CD3+, and CD4+/CD8+ T cells will be determined. The shifts in patients' quality of life, as measured by the Karnofsky Performance Scale and the EORTC core quality of life questionnaire (QLQ-C30), will constitute secondary outcome measures. Concomitantly, the 5-year survival rate and the likelihood of recurrence will be ascertained. Each visit will entail a formal assessment concerning safety and potential adverse reactions. This ongoing study will provide clinical data on the safety and effects of press needle intervention compared to a sham intervention on immune function and quality of life in patients who have undergone breast cancer resection. The Chinese Clinical Trial Registry, ChiCTR2000040100, is where the trial's registration is archived. Registration was completed on November 21, 2020.

This study investigated the correlation between oral microbiota and tongue coating in patients with chronic gastritis, analyzing the microbial community structure across different tongue coating appearances.
16S rDNA gene sequencing and bioinformatics analysis provided insights into the evolving microbial communities and their associations among chronic gastritis patients, healthy participants, and individuals with variations in tongue fur. Simultaneously, the debate encompassed the connection between the intensity of gastritis and the microbial populations residing on the tongue.
Chronic gastritis patients' tongue fur displayed a significantly unique microbial diversity when compared to healthy individuals. Between patients with extra tongue fur and healthy individuals, there were considerable differences in the diversity and relative abundance of bacterial communities, but not in healthy individuals. Relative abundances of oral bacteria greater than 1% but below 0.05% were most prevalent among the various tongue fur flora, including 12 phyla such as and , and 256 genera such as and .
A connection existed between the presence of tongue fur and the variations in oral flora, particularly in patients with chronic gastritis. Accordingly, the notable microbial composition of the oral cavity could potentially stimulate further research exploring the correlation between tongue examination and oral microbiota in patients with chronic gastritis.
A study revealed a connection between the alterations in the oral microbiome and the appearance of tongue coating in patients with chronic gastritis. immunoregulatory factor Subsequently, the considerable microbial community could prompt further exploration of the relationship between tongue assessment and oral microorganisms in patients suffering from chronic gastritis.

To examine the clinical efficacy of acupuncture treatments, incorporating stimulation along fascial pathways, meridians, and nerves, combined with ultrasound-guided nerve blockade, in treating postherpetic neuralgia.
Between May 2019 and June 2021, a total of sixty-one outpatients suffering from post-herpetic neuralgia of the chest and back, attributable to herpes zoster, were recruited at the Pain Department of Xiyuan Hospital, part of the China Academy of Chinese Medical Sciences. A random process divided them into two teams. Thirty-one patients in the control group underwent ultrasound-guided thoracic paravertebral nerve block (PVB) treatment only. One patient discontinued the study, leaving thirty participants. Meanwhile, thirty patients in the observation group received acupuncture on fascia, meridians, and nerves, plus ultrasound-guided PVB. Both the control and observation groups received weekly treatment for four weeks.